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KMID : 1040020200110010001
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International Journal of Pain
2020 Volume.11 No. 1 p.1 ~ p.10
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Central Post-Stroke Pain: A Review Focusing on Pathophysiology
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Bae Hee-Won
Kang Min-Ju
Ha Sang-Won
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Abstract
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Central post-stroke pain (CPSP) is one of the complication of ischemic stroke that can occur in 1-12% of patients. CPSP is related with both neuropathic and nociceptive pain. Pain is characterised by sudden, brief pain and presented as dysaethesia, allodynia and hyperalgesia. The area of pain corresponds to the body parts that corresponds to the brain lesion. Various mechanisms are presented as hypothesis, but there are no clearly defined. Commonly, It is known to be caused by the hyperexcitability of pain conduction pathway, as well as disinhibition of central inhibitory pathway. While pharmacological and non-pharmachological treatments are being tried, clinically, they are mainly prescribed amitriptyline. It would be find effective treatment if more clear mechanism are identified through prospective research.
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KEYWORD
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central post-stroke pain, allodynia, hyperalgesia, central sensitization, amitriptyline
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